Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy
نویسندگان
چکیده
منابع مشابه
Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy.
Intrahepatic cholestasis of pregnancy and drug-induced cholestasis are two clinically important forms of acquired cholestatic liver disease. The understanding of the underlying mechanisms of acquired cholestasis has recently made considerable progress by the identification of canalicular ATP-binding cassette (ABC) transporters as likely targets for these forms of cholestasis. Cholestasis of pre...
متن کاملIntrahepatic cholestasis of pregnancy.
Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including spon...
متن کاملINTRAHEPATIC CHOLESTASIS OF PREGNANCY Genetic background, epidemiology and hepatobiliary consequences
................................................................................................... 8 INTRODUCTION ......................................................................................... 9 REVIEW OF THE LITERATURE ................................................................. 10 1. Physiology of bile acids .......................................................................
متن کاملGenetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy.
BACKGROUND AND AIMS The aim of this study was to investigate the genetic aetiology of intrahepatic cholestasis of pregnancy (ICP) and the impact of known cholestasis genes (BSEP, FIC1, and MDR3) on the development of this disease. PATIENTS AND METHODS Sixty nine Finnish ICP patients were prospectively interviewed for a family history of ICP, and clinical features were compared in patients wit...
متن کاملHealth behavior after intrahepatic cholestasis of pregnancy
Background: Pregnancy is an opportunity to adopt favorable health behaviors. We studied whether intrahepatic cholestasis of pregnancy (ICP) promotes favorable health behavior in later life. Design: A prospective controlled cohort study. The method was a questionnaire survey in 2010 among 575 women with ICP and 1374 controls, all having delivered between the years 1969 and 1988 in Tampere Univer...
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ژورنال
عنوان ژورنال: Seminars in Liver Disease
سال: 2010
ISSN: 0272-8087,1098-8971
DOI: 10.1055/s-0030-1253224